SPDT Sonodynamic Photodynamic Therapy - A Cancer Treatment


Search This Site for information

SPDT Research Information

The following represents a list of papers which are provided as guidance for healthcare professionals interested in SPDT as an approach to treating cancer.  Two papers have been critical about the claims made for SPDT and these are references 20 and 21.  

1. Activated Cancer Therapy Using Light and Ultrasound - A Case Series of Sonodynamic Photodynamic Therapy in 115 Patients Over a 4 Year Period. Julian Norman Kenyon, Richard James Fuller and Thomas Joseph Lewis Published in Current Drug Therapy, 2009, 4, 179-193

2. Outcome Measures Following Sonodynamic Photodynamic Therapy - A Case Series. Julian Norman Kenyon and Richard James Fuller, Current Drug Therapy, 2011, 6, 12-16

3. Sonodynamic Therapy - a review of the synergistic effects of drugs and ultrasound. Ionel Rosenthal, Joe Z Sostaric, Peter Reisz, Ultrasonics Sonochemistry 11 (2004) 349-363

4. Sonodynamic and Photodynamic Therapy in Advanced Breast Carcinoma: A report of three cases. Xiahuai Wang MD, Weimim ZhangMD, Zhiyong Xu MD, Yifan Lu PhDo, Doug Mitchell PhD and Ralph W Moss PhD. Department of Oncology, Liu Hua Hospital, Guangzhou, China

5. Primary clinical use of Sonodynamic therapy (SDT) for advanced breast cancer. (External link) American Society of Clinical Oncology 2008 Breast Cancer Symposium, T.J. Lewis PhD, X Wang MD.

6. Photodynamic Therapy of Cancer: An Update Patrizia Agostinis PhD, Kristian Berg PhD, Keith A Cengel MD,PhD, Thomas H Foster PhD, Albert W Girotti PhD, Sandra O Gollnick PhD, Stephen M Hahn MD, PhD, Johan Moan PhD, Pawel Mroz MD, PhD, Dominika Nowes MD, PhD, Jaques Peitte PhD, Brian C Wilson PhD, Jakub Golab MD, PhD. CA Cancer J Clin 2011,61:250-281

7. Toxicity and Cytopathogenic Properties Toward Human Melanoma Cells of Activited Cancer Therapeutics in Zebra Fish (External Link) Thomas J Lewis PhD. Integrative Cancer Therapies XX(X) 1-9

8. The effects of ultrasound and light on indocyanine green-treated tumour cells and tissues Nilokitsa Nomikou, Christine Sterret, Ciara Arthur, Bridgeen McCaughan, John F Callan and Anthony P McHale. ChemMedChem. 2012 Aug;7(8):1465-71

9. Microbubble-sonosensitiser conjugates as therapeutics in Sonodynamic therapy. Nikolitsa Nomikou, Colin Fowley, Niall M Byrne, Bridgeen McCaughan, Anthony P McHale and John F Callan Chem. Commun., 2012,48,8332-8334

10. Ultrasound-enhanced drug dispersion through solid tumours and its possible role in aiding ultrasound-targeted cancer chemotherapy. Nikolitsa Nomikou, Ying Suet Li, Anthony P McHale, Cancer Letters 288 (2010) 94-98

11. Enhancing ultrasound-mediated cell membrane permeabilisation (sonoporation) using a high frequency pulse regime and implications for ultrasound-aided cancer chemotherapy.  Li YS, Reid CN, McHale AP - Cancer Lett. 2008 Aug 8;266(2):156-62. doi: 10.1016/j.canlet.2008.02.041. Epub 2008 Mar 25

12. Enhanced ROS production and cell death through comibined photo-and-sono-activation of conventional photosensitizing drugs. Bridget McCaughan, Claire Rouanet, Colin Fowley, Nikolitsa Nomikou, Anthony P McHale, Paul A McCarron, John F Callan.  Bioorganix and Medicinal Chemistry Letters 21 (2011) 5750-5752

13. The Tumoricidal Effect of Sonodynamic Therapy (SDT) on S-180 Sarcoma in Mice - Xiaohuai Wang, Thomas J Lewis and Doug Mitchell. Integr. Cancer Ther. 2008; 7; 96

14. Prostate Cancer Treated by Sonodynamic and Photodynamic Therapy (SPDT, NGPDT).Donald Murphy 1,2. Brian Meade 3, Avni Sali 3. Geelong Private, St John of God and Colac Hospitals1, skills Laboratory RACS. Melbourne 2, National Institute of Integrative Medicine Melbourne3.Urological Society of Australia and New Zealand No. 089 April 2013

15. Sonodynamically induced cell damage using Rose Bengal derivative - Nami Sugita, Yumiko Iwase, Nagahiko Yumita, Toshihiro Ikeda and Shin-Ichiro Umemura. Anticancer Research 30: 3361-3366 (2010)

16. Sonodynamic Therapy of Cancer using Novel Sensitizers - Masaride Kuroki, Hachimine K, Abe H, Shibaguchi H, Kuroki M, Maekawa S, Yanagisawa J, Kinugasa T, Tanaka T, Yamashita Y. Anticancer Res. 2007 Nov-Dec;27(6A):3673-7.

17. Enhancement of Anti Tumor Immunity using Photodynamic Therapy  - Sandra O Gollnick & CraigM Brackett  Immunol Res DOI 10, 1007/s12026-009-8119-4

18. Sonodynamic and Photodynamic therapy in Advanced refractory Breast Cancer - a Report of 3 Cases - Wang X, Zhang W, Xu Z, Luo Y, Mitchell D, Moss RW. - Integr Cancer Ther. 2009 Sep;8(3):283-7. doi: 10.1177/1534735409343693

19. Primary clinical use of the sono-photo-dynamic therapy for advanced esophagocadiac and gastric adenocarcinoma (2014 Abstract - external link). Lucy Qing Li, Xiaohuai Wang, Iris Wenyin Zhang, Douglas Mitchell;

20. NHS Choices article on Photodynamic therapy (PDT), 'next-generation' PDT and sonodynamic therapy

21. Rationale of Combined PDT and SDT Modalities for Treating Cancer Patients in Terminal Stage: The Proper Use of Photosensitizer - Zheng Huang MD, PhD,1 Harry Moseley PhD, FInstP, FIPEM,2 Stephen Bown MD, FRCP3 2012

22. Optimising ultrasound-mediated gene transfer (sonoporation) in vitro and prolonged expression of a transgene in vivo: Potential applications for gene therapy of cancer Ying Suet Li, Emma Davidson, Cherith N. Reid, Anthony P. McHale

23. Water soluble quantum dots as hydrophilic carriers - Colin Fowley et al

24. Photodynamic Therapy of Cancer: An Update - Agostinis et al from CA - The Cancer Journal for Physicians -July/Aug 2011

25. Regulatory T Cells in Cancer Treatment (PDF)

26. Free hydroxyl radical dosimetry by using 1 MHz low level ultrasound waves

27. Sonodynamic Photodynamic Therapy Presentation  - (PDF) or (Zip file)

Links to other sites with Information on SPDT

Theses sites may help healthcare professionals find further information on this and other associated treatments.

What is SPDT/SDT?

The Canceractive Guide

American Society of Clinical Oncology - Sonodynamic Therapy paper

A systematic review of photodynamic therapy in the treatment of precancerous skin conditions

In 1995 a paper was published looking at “Treatment of head and neck cancer with photodynamic therapy: results after one year”

Why doesn’t photodynamic therapy (PDT) cause any noticeable damage to human tissue?

Physician discussing treatment

Further Information

If you have any information you would like to add to this site or comments on the content of this site please send details to editor@spdt.org.uk

If you have been a patient and would like to share your experiences please also contact editor@spdt.org.uk